Trabajo científico
Novelty phospolipid formulation as biodegradable injectable DDS
C. Luengo, D.R. Serrano, J.J. Torrado, M.P. Ballesteros
Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy, Complutense University of Madrid, Spain
Biodegradable injectable in situ forming drug delivery systems (DDS) represent an attractive alternative to microspheres and implants as parenteral depot systems. The aim of this work is to study the influence of different excipients (lipidic versus non lipidic) on the efficacy of these systems.
The controlled released of bioactive molecules via solid/semisolid in situ forming systems has a number of advantages such as ease of administration, less complication fabrication and less stressful manufacturing conditions for sensitive drug molecules. The excipients used are key factors for getting the success of these systems.
It has been studied how phospholipidic systems due to its mimetic endothelial cell membrane properties and its non-thrombogenic and antifouling surfaces, are suitable for the development of these novelty systems.
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